Because cellular content of blood is removed prior to testing viscosity (and, in the case of serum, clotting factors as well), plasma and serum viscosity tests do not provide a direct representation of a subject’s hemodynamic or hemorheologic status. Plasma and serum viscosity are also used in a number of clinical diagnoses such as Waldenström macroglobulinemia. Plasma and serum viscosity tests are useful to detect an acute phase reaction or severe inflammatory response such as in sepsis. Despite its U-shaped capillary design, the Ostwald tube is more primitive than rotational viscometers. Using an Ostwald tube or a rotational viscometer, the viscosity of plasma and serum can be easily quantified, and these methods are widely used in hospitals and clinical reference laboratories. Cellular content is removed from plasma prior to analysis, and in the case of serum, clotting factors have also been removed.
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